“The Original EcoSphere® is the world’s first totally enclosed ecosystem – a complete, self-contained and self-sustaining miniature world encased in glass. Be wary of inferior and lower quality imitations. Easy to care for, an EcoSphere is an incredible learning tool that can provide powerful insights about life on our own planet… and provide a glimpse of technology that’s shaping the future of space exploration.”
So cool. Will have to get one some day. [via @curisma]
An Analysis of the Existing Regulatory Framework and Recommendations for Alternative Frameworks
A team of researchers at the University of Maryland Baltimore is studying federal regulation of probiotics under a grant from NIH’s Human Microbiome Project (HMP). A portion of HMP funds were set aside to study the Ethical, Legal, and Social Implications (often referred to as the ELSI issues) of the Project’s scientific goals. The probiotics project is an interdisciplinary collaboration between faculty members from the University of Maryland Schools of Law, Pharmacy and Medicine.
This site is chock-full of info on probiotics policy, regulations, and science. Really good stuff.
“Artificial two-dimensional biological habitats were prepared from porous polymer layers and inoculated with the fungus Penicillium roqueforti to provide a living material. Such composites of classical industrial ingredients and living microorganisms can provide a novel form of functional or smart materials with capability for evolutionary adaptation. We demonstrated a design of such living materials and showed both active (eating) and waiting (dormant, hibernation) states with additional recovery for reinitiation of a new active state by observing the metabolic activity over two full nutrition cycles of the living material (active, hibernation, reactivation). This novel class of living materials can be expected to provide nonclassical solutions in consumer goods such as packaging, indoor surfaces, and in biotechnology.”
Hm. Some really practical uses of microbes – impregnating fabrics to provide bioactive activity.
A bit of history:
I experienced a huge brain- and world-expanding time during my Nokia Lifeblog years (2004-05). Early on, we paired up with Six Apart (via Marko Ahtisaari and Joi Ito), and I spent a lot of time under Loïc LeMeur’s wing promoting blogging, Six Apart, and Lifeblog, and meeting some of the key movers in the nascent Web 2.0 (thank you, Loïc).
In those days, I pushed for the fusion of web and mobile, started seeing how everything was coming in as streams, and how people started exuding their own lifestreams. The next logical idea was how to bring that together.
In 2006, the poster child was NetVibes. But I though we could do better. Some started talking about personal aggregators, Digital Lifestyle Aggregators, the widgetization of everything.
Morsels:
For me, the sweetspot was to be the one holding all the morsels (He who hold the morsels, holds the experience. “The structure holding the morsels becomes the experience” – Fabio Sergio), a dynamic dashboard where all my social streams come in, where I could mix and match, and then send all the things of note out back into the streams.
This was my original vision of what should have become Ovi.com. Alas, I could point to so many places where the harpoon was sunk and twisted into me (and into those who stayed on), but I had been given a huge wad of cash to do it, and I f-ed it up by not channeling my inner-Jobs and insisting we stay true to vision.
Lesson learned. Enough self-pitying. I had my chance and blew it.
In the time since, I have seen attempts to create similar services, and even some blatant suggestions from some great thinkers as to what was missing in this age of lifestreams (which I thought would be in 2008). But nothing really took hold (though I think Seesmic desktop shows promise).
Bottlenose:
And, lo, on comes a new service. And from a brilliant semantic web guy with a track record of actually coming out with things that I thought approached what I wanted to see.
“Bottlenose is a new social media dashboard for influencers of all stripes. But it’s not just for posting and reading; it helps you filter and manage your networks with semantics and machine learning. It’s all Web-based, written in HTML 5 and Javascript. It does the data crunching on the browser side (for the non-pro users), so you get native performance behind these major operations reading and parsing your stream.”
Read this article from Read Write Web
I signed up and have been checking it out. Of course, I’m sure this is better than whatever I would have built in 2007, given how the Web and mobile world have changed since then. I think one issue that could come to bite is any deviation from the usual UI folks are accustomed to for scanning info and streams. The weirder, the less likely someone will use it without feeling geeky.
In any case, I’m excited to play with it. If you check it out, let me know what you think of it.
One more thing:
I’ve also evolved my thinking since 2007 and think Bottlenose should be a P2P system. Take back the Cloud!
Image from the Read Write article on Bottlenose.
“Now, a new study by Eric Martens, David Bolam, and colleagues has looked into how a pair of the most common species of gut bacteria metabolize polysaccharides, showing that each bacterium is highly specialized. Using a high-throughput system for feeding the bacteria dozens of kinds of carbohydrates, one at a time, and tracking the bacteria’s gene expression, they were able to see how these microbes have tailored themselves to fill specific niches in the gut.”
This is a really good study. For me, a better understanding of the gut metabolic ecology will allow for the development of better probiotics. One interesting finding in this study is that some bug don’t grow well on simple sugar because their sensors are built for complex sugars. Made me think of folks in developed world and what effect eating more simple sugars (high-fructose corn syrup) has on gut flora and any consequential obesity.
“Many yoghurts are loaded with live bacteria, and labelled with claims that consuming these microorganisms can be good for your health. But a study published today shows that such yoghurts have only subtle effects on the bacteria already in the gut and do not replace them.”
Yes, but the paper goes to point out that both in humans and mice, there was an upregulation of polysaccharide metabolism genes in the existing gut microbes. Hm, there are some serious implications there.
“This study has identified the first bacterial genes required for induction of settlement and metamorphosis of a marine invertebrate animal.”
This is an interesting genetic study as to what in the bacteria cause the induction of settlement and metamorphosis. Hooray for Nature for making this paper open so that I could read it. Though the paper focused on the genetic aspects and didn’t speculate (unless I missed it) how this connection arose evolutionarily. My speculation is that the bacteria is an environmental marker, telling the worm where to settle and grow.
Cool, huh?
A Global Strategic Business Report
This report analyzes the worldwide markets for Probiotics in US$ Million. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Middle East, and Latin America. Annual estimates and forecasts are provided for each region for the period 2007 through 2015. Also, a seven-year historic analysis is provided for these markets. The report profiles 119 companies including many key and niche players such as BioGaia Biologics AB, Chr. Hansen A/S, Danisco A/S, Groupe Danone, Institut Rosell, Lifeway Foods, Inc., Natren, Inc., Nestlé Nutrition, Probi AB, Seven Seas Ireland Ltd., Stonyfield Farm, Valio Ltd., and Yakult Honsha Co., Ltd. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
Alas, too expensive for me to purchase. But if I were really in the business, probably worth it.
“Global Industry Analysts (GIA) predicts the global probiotics market will be worth $28.8bn by 2015, even though the market is still considered to be in infancy. “
I like this.
“Supplements containing a combination of Lactobacillus salivarius and fructo-oligosaccharide for eight weeks were associated with significant reductions in measures of the severity of eczema, compared with a control group receiving only prebiotics, according to findings published in the British Journal of Dermatology.”
In addition to the usual yogurt bugs, I am starting to see salivarius popping up more frequently. It’s from the mouth, by the way.