James King: Dressing the meat of tomorrow – Scientific American

"Growing meat without the animal sounds like a simple idea. Certainly much simpler than manipulating the genetic code. In reality there are hidden practicalities which only become apparent when you deal with the real materials and processes of biotechnology, or at least work closely with people that do. The experience of working in the lab was inspiring, but it also made me reassess the way I should work as a designer engaging with biotechnology. I realised that I couldn't keep the science at arm's length but should instead take every opportunity to get into the lab and, as Oron Catts likes to say, get my hands wet."

Great review article on synthetic meat from a guy who has his a sharp eye and creative imagination on the implications of synthetic biology.

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Microbes Give Mice Intestinal Fortitude – ScienceNOW

"The findings add to the growing understanding of the complex relationship between our health and the bacteria living in and on our bodies. They also add to the growing conviction that it might one day be possible to curb diarrhea, and prevent other diseases, by making sure our guts have the right complement of bacteria."

I saw a Nature paper on how <a href="http://www.nature.com/nature/journal/v469/n7331/full/nature09646.html">Bifidobacteria can protect from enteropathogenic infection through production of acetate.</a> Both these papers suggest that there may be ways to control bacterial pathogenesis with other bacteria. Can you say probiotics?

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Plastic – Too Good to Throw Away – NYTimes.com

"“Eliminating plastic is one of the greenest actions you can do to lower your eco-footprint,” one noted while participating in a recent online challenge to be plastic-free. Is this true? Shunning plastic may seem key to the ethic of living lightly, but the environmental reality is more complex."

Really clever article questioning anti-plastic trends. The main point is not that plastic is bad but that the most harming uses of plastic have to do with behavior not the plastic (such as single use bags).

This is a good read.

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Structural biology: Breaking the protein rules : Nature News

This review brings together the research that counters the fallacy that proteins need to have a defined structure (as seen in crystal structures) to have a function. There has been a range of interesting findings regarding the requirement of disorder in protein structures. And folks are starting to tease out where and how disorder is useful.

To me, I see proteins as jiggly string with a propensity to have a certain shape. If there's a part that hangs out there, it's not necessarily totally disordered – the stretch has a conformation space it prefers, even if that space is large. And in that sampling of conformational space, that "disordered" stretch is honing in on its function.

So, no, I'm not surprised or worried bout the disorder and this paper does a great job in giving disorder its due.

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Friendly bacteria fight the flu : Nature News

“Neomycin-sensitive bacteria naturally present in the mice’s bodies provided a trigger that led to the production of T cells and antibodies that could fight an influenza infection in the lungs. When antibiotics eliminated the bacteria, inflammasomes failed to launch and the virus multiplied.”

Another paper of bacteria modulating the immune response for the whole body. I’ve seen a few that tease out different bacteria with different effects. The key thing that all these papers find is that that gut microbes can modulate immune response. If that’s the case, then we need to not only be mindful of the antibiotics we take, but also what we eat. The flora in your gut could protect you from getting sick from viruses and other nasties.

[As an aside: gotta chuckle at “inflammasome”. Do the ‘omes never end?]

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Do gut bacteria worsen malnourishment? : Nature News

“Ultimately, Smith would like to identify a bacterium or set of bacteria that protects children from kwashiorkor, and add it to the emergency rations handed out to starving children, or give it to them beforehand. “Maybe we can do earlier interventions — before they suffer,” she says.”

Another interesting finding teasing out the importance of gut bacteria in human health. An interesting outcome would be creating a probiotic to prevent or recover from malnutrition.

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Could Amateur Taxonomists Catalog Earth’s Fauna? – ScienceInsider

"Taxonomy has a reputation as one of science's least glamorous fields, and experts have been sounding an alarm over declining funding and a global dearth of practitioners. With extinctions estimated to outnumber discoveries of new species and many of Earth's most diverse taxa still unaccounted for, they say the effort to identify and catalog organisms is more critical than ever before. Now some researchers are calling for taxonomists to open wide their profession's gates to amateur scientists, as the popular GalaxyZoo Web site has begun to do with citizen astronomers."

Citizen science to the rescue!

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